Genvoya(tenofovir alafenamide)
Biktarvy, Descovy, Genvoya, Odefsey, Symtuza, Tenofovir Alafenamide, Vemlidy (tenofovir alafenamide) is a small molecule pharmaceutical. Tenofovir alafenamide was first approved as Genvoya on 2015-11-05. It is used to treat chronic hepatitis b in the USA. It has been approved in Europe to treat hepatitis b and HIV infections.
Download report
Favorite
Events Timeline
Commercial
Clinical
Drug
Target
Variants
Financial
Trends
Safety
Events Timeline
5D
1M
3M
6M
YTD
1Y
2Y
5Y
Max
Events
FDA approval date
EMA approval date
Patent expiration date
Study first post date
Last update post date
Start date
Primary completion date
Completion date
Results first post date
Mock data
Subscribe for the real data
Subscribe for the real data
Commercial
Trade Name
FDA
EMA
Vemlidy (generic drugs available since 2023-03-30)
CombinationsBiktarvy, Descovy, Genvoya, Odefsey, Symtuza
Drug Products
FDA
EMA
New Drug Application (NDA)
New Drug Application (NDA)
Abbreviated New Drug Application (ANDA)
Abbreviated New Drug Application (ANDA)
Bictegravir sodium
+
Emtricitabine
+
Tenofovir alafenamide fumarate
Tradename | Company | Number | Date | Products |
|---|---|---|---|---|
| BIKTARVY | Gilead Sciences | N-210251 RX | 2018-02-07 | 2 products, RLD, RS |
Cobicistat
+
Darunavir
+
Emtricitabine
+
Tenofovir alafenamide fumarate
Tradename | Company | Number | Date | Products |
|---|---|---|---|---|
| SYMTUZA | Johnson & Johnson | N-210455 RX | 2018-07-17 | 1 products, RLD, RS |
Cobicistat
+
Elvitegravir
+
Emtricitabine
+
Tenofovir alafenamide fumarate
Tradename | Company | Number | Date | Products |
|---|---|---|---|---|
| GENVOYA | Gilead Sciences | N-207561 RX | 2015-11-05 | 1 products, RLD, RS |
Emtricitabine
+
Rilpivirine hydrochloride
+
Tenofovir alafenamide fumarate
Tradename | Company | Number | Date | Products |
|---|---|---|---|---|
| ODEFSEY | Gilead Sciences | N-208351 RX | 2016-03-01 | 1 products, RLD, RS |
Emtricitabine
+
Tenofovir alafenamide fumarate
Tradename | Company | Number | Date | Products |
|---|---|---|---|---|
| DESCOVY | Gilead Sciences | N-208215 RX | 2016-04-04 | 2 products, RLD, RS |
Tenofovir alafenamide fumarate
Tradename | Company | Number | Date | Products |
|---|---|---|---|---|
| VEMLIDY | Gilead Sciences | N-208464 RX | 2016-11-10 | 1 products, RLD, RS |
Indications
FDA
EMA
Indication | Ontology | MeSH | ICD-10 |
|---|---|---|---|
| chronic hepatitis b | EFO_0004239 | D019694 | B18.1 |
Agency Specific
FDA
EMA
Expiration | Code | ||
|---|---|---|---|
EMTRICITABINE / TENOFOVIR ALAFENAMIDE FUMARATE, DESCOVY, GILEAD SCIENCES INC | |||
| 2029-01-07 | ODE-457 | ||
| 2024-09-28 | ODE-284, ODE-285 | ||
BICTEGRAVIR SODIUM / EMTRICITABINE / TENOFOVIR ALAFENAMIDE FUMARATE, BIKTARVY, GILEAD SCIENCES INC | |||
| 2028-10-07 | ODE-378 | ||
| 2026-06-18 | ODE-256 | ||
| 2024-02-24 | M-82 | ||
TENOFOVIR ALAFENAMIDE FUMARATE, VEMLIDY, GILEAD SCIENCES INC | |||
| 2025-10-17 | NPP | ||
Patent Expiration
Patent | Expires | Flag | FDA Information |
|---|---|---|---|
| Cobicistat / Darunavir / Emtricitabine / Tenofovir Alafenamide Fumarate, Symtuza, Janssen Prods | |||
| 10786518 | 2038-07-19 | U-2978 | |
| 10039718 | 2032-10-06 | DP | |
| 8148374 | 2029-09-03 | DS, DP | U-1279, U-2353, U-2364, U-2365, U-2766, U-2767, U-2768 |
| 7700645 | 2026-12-26 | DS, DP | |
| 8518987 | 2024-02-16 | DS, DP | |
| Bictegravir Sodium / Emtricitabine / Tenofovir Alafenamide Fumarate, Biktarvy, Gilead Sciences Inc | |||
| 10548846 | 2036-11-08 | DP | |
| 11744802 | 2036-11-08 | DP | |
| 9708342 | 2035-06-19 | DS, DP | |
| 10385067 | 2035-06-19 | U-257 | |
| 9216996 | 2033-12-19 | DS, DP | |
| 9732092 | 2033-12-19 | DS, DP | |
| 8754065 | 2032-08-15 | DS, DP | U-257, U-999, U-1259, U-1275, U-1663, U-2352, U-2765 |
| 9296769 | 2032-08-15 | DS, DP | U-257, U-999, U-1259, U-1275, U-1663, U-2352, U-2765 |
| 7390791 | 2025-04-17 | DS, DP | |
| Cobicistat / Elvitegravir / Emtricitabine / Tenofovir Alafenamide Fumarate, Genvoya, Gilead Sciences Inc | |||
| 8633219 | 2030-04-30 | DP | U-257 |
| 9891239 | 2029-09-03 | DP | U-257 |
| 7635704 | 2026-10-26 | DS, DP | U-257 |
| 8981103 | 2026-10-26 | DS, DP | |
| 7176220 | 2026-08-27 | DS, DP | U-257 |
| Emtricitabine / Rilpivirine Hydrochloride / Tenofovir Alafenamide Fumarate, Odefsey, Gilead Sciences Inc | |||
| 7125879 | 2025-04-21 | DS, DP | U-257 |
ATC Codes
J: Antiinfectives for systemic use
— J05: Antivirals for systemic use
— J05A: Direct acting antivirals
— J05AF: Nucleoside and nucleotide reverse transcriptase inhibitors
— J05AF13: Tenofovir alafenamide
— J05AR: Antivirals for treatment of hiv infections, combinations
— J05AR17: Emtricitabine and tenofovir alafenamide
— J05AR18: Emtricitabine, tenofovir alafenamide, elvitegravir and cobicistat
— J05AR19: Emtricitabine, tenofovir alafenamide and rilpivirine
— J05AR20: Emtricitabine, tenofovir alafenamide and bictegravir
— J05AR22: Emtricitabine, tenofovir alafenamide, darunavir and cobicistat
HCPCS
No data
Clinical
Clinical Trials
1273 clinical trials
View more details
Mock data
Subscribe for the real data
Subscribe for the real data
Indications Phases 4
Indication | MeSH | Ontology | ICD-10 | Ph 1 | Ph 2 | Ph 3 | Ph 4 | Other | Total |
|---|---|---|---|---|---|---|---|---|---|
| Hiv infections | D015658 | EFO_0000764 | B20 | 39 | 108 | 149 | 131 | 97 | 499 |
| Hiv | D006678 | — | O98.7 | 27 | 22 | 40 | 74 | 47 | 204 |
| Chronic hepatitis b | D019694 | EFO_0004239 | B18.1 | 19 | 47 | 23 | 50 | 52 | 186 |
| Hepatitis b | D006509 | — | — | 8 | 16 | 11 | 20 | 17 | 70 |
| Healthy volunteers/patients | — | — | — | 24 | — | — | 7 | 2 | 33 |
| Acquired immunodeficiency syndrome | D000163 | EFO_0000765 | B20 | 2 | 7 | 14 | 3 | 3 | 26 |
| Hiv-1 | D015497 | — | — | 2 | 7 | 9 | 5 | — | 22 |
| Infections | D007239 | EFO_0000544 | — | — | 6 | 9 | 3 | 3 | 21 |
| Tuberculosis | D014376 | EFO_0000774 | A15-A19 | 3 | 3 | 2 | 3 | 4 | 15 |
| Hepatitis c | D006526 | — | B19.2 | 3 | 2 | 1 | 4 | 4 | 13 |
Show 59 more
Indications Phases 3
Indication | MeSH | Ontology | ICD-10 | Ph 1 | Ph 2 | Ph 3 | Ph 4 | Other | Total |
|---|---|---|---|---|---|---|---|---|---|
| Hepatocellular carcinoma | D006528 | — | C22.0 | — | — | 2 | — | 6 | 8 |
| Covid-19 | D000086382 | — | U07.1 | — | 3 | 5 | — | 2 | 7 |
| Metabolic syndrome | D024821 | EFO_0000195 | E88.810 | — | 1 | 1 | — | 1 | 3 |
| Hyperlipidemias | D006949 | HP_0003077 | E78.5 | — | — | 1 | — | 1 | 2 |
| Breast feeding | D001942 | — | — | — | — | 1 | — | 1 | 2 |
| Sars-cov-2 | D000086402 | — | — | — | 1 | 2 | — | — | 2 |
| Hiv seronegativity | D018023 | — | — | — | 1 | 1 | — | 1 | 2 |
| Liver transplantation | D016031 | EFO_0010682 | — | — | — | 1 | — | 1 | 2 |
| B-cell lymphoma | D016393 | — | — | — | — | 1 | — | 1 | 2 |
| Chronic hepatitis d | D019701 | — | — | — | 1 | 1 | — | — | 2 |
Show 7 more
Indications Phases 2
Indication | MeSH | Ontology | ICD-10 | Ph 1 | Ph 2 | Ph 3 | Ph 4 | Other | Total |
|---|---|---|---|---|---|---|---|---|---|
| Hepatitis d | D003699 | EFO_0007304 | — | — | 4 | — | — | 1 | 5 |
| Gender identity | D005783 | — | — | 1 | 1 | — | — | 3 | 4 |
| Behavior and behavior mechanisms | D001520 | — | — | 1 | 1 | — | — | 2 | 3 |
| Pulmonary tuberculosis | D014397 | EFO_1000049 | A15 | 1 | 1 | — | — | — | 2 |
| Biliary liver cirrhosis | D008105 | — | K74.3 | — | 1 | — | — | 1 | 2 |
| Lipodystrophy | D008060 | HP_0009125 | E88.1 | — | 2 | — | — | — | 2 |
| Parasitemia | D018512 | — | — | 1 | 1 | — | — | — | 1 |
| Progressive multifocal leukoencephalopathy | D007968 | EFO_0007455 | A81.2 | — | 1 | — | — | — | 1 |
| Htlv-ii infections | D015491 | EFO_1001349 | — | — | 1 | — | — | — | 1 |
| Amphetamine-related disorders | D019969 | EFO_0004701 | F15 | — | 1 | — | — | — | 1 |
Show 8 more
Indications Phases 1
Indication | MeSH | Ontology | ICD-10 | Ph 1 | Ph 2 | Ph 3 | Ph 4 | Other | Total |
|---|---|---|---|---|---|---|---|---|---|
| Contraception behavior | D003268 | — | — | 1 | — | — | — | 1 | 2 |
| Insulin resistance | D007333 | HP_0000855 | E88.819 | 2 | — | — | — | — | 2 |
| Heart disease risk factors | D000082742 | — | — | 1 | — | — | — | — | 1 |
| Lipid metabolism disorders | D052439 | — | — | 1 | — | — | — | — | 1 |
| Gender dysphoria | D000068116 | — | F64 | 1 | — | — | — | — | 1 |
| Transgenes | D019076 | — | — | 1 | — | — | — | — | 1 |
| Hepacivirus | D016174 | — | — | 1 | — | — | — | — | 1 |
| Amyotrophic lateral sclerosis | D000690 | HP_0007354 | G12.21 | 1 | — | — | — | — | 1 |
| Non-alcoholic fatty liver disease | D065626 | EFO_0003095 | K75.81 | 1 | — | — | — | — | 1 |
| Lung diseases | D008171 | HP_0002088 | J98.4 | 1 | — | — | — | — | 1 |
Show 1 more
Indications Without Phase
Indication | MeSH | Ontology | ICD-10 | Ph 1 | Ph 2 | Ph 3 | Ph 4 | Other | Total |
|---|---|---|---|---|---|---|---|---|---|
| Risk reduction behavior | D040242 | — | — | — | — | — | — | 3 | 3 |
| Aging | D000375 | GO_0007568 | R41.81 | — | — | — | — | 3 | 3 |
| Sustained virologic response | D000072230 | — | — | — | — | — | — | 2 | 2 |
| Inflammation | D007249 | MP_0001845 | — | — | — | — | — | 2 | 2 |
| Portal hypertension | D006975 | EFO_0000666 | K76.6 | — | — | — | — | 2 | 2 |
| Self efficacy | D020377 | — | — | — | — | — | — | 2 | 2 |
| Pregnancy rate | D018873 | — | — | — | — | — | — | 2 | 2 |
| Female genital diseases | D005831 | EFO_0009549 | N85 | — | — | — | — | 1 | 1 |
| Bone density | D015519 | EFO_0003923 | M85 | — | — | — | — | 1 | 1 |
| Job syndrome | D007589 | EFO_0003775 | D82.4 | — | — | — | — | 1 | 1 |
Show 22 more
Epidemiology
Epidemiological information for investigational and approved indications
View more details
Drug
General
| Drug common name | Tenofovir alafenamide |
| INN | tenofovir alafenamide |
| Description | Tenofovir alafenamide is an L-alanine derivative that is isopropyl L-alaninate in which one of the amino hydrogens is replaced by an (S)-({[(2R)-1-(6-amino-9H-purin-9-yl)propan-2-yl]oxy}methyl)(phenoxy)phosphoryl group. A prodrug for tenofovir, it is used (as the fumarate salt) in combination therapy for the treatment of HIV-1 infection. It has a role as an antiviral drug, a HIV-1 reverse transcriptase inhibitor and a prodrug. It is a L-alanine derivative, a phosphoramidate ester, an ether, a member of 6-aminopurines and an isopropyl ester. It is functionally related to an adenine. It is a conjugate base of a tenofovir alafenamide(1+). |
| Classification | Small molecule |
| Drug class | antivirals |
| Image (chem structure or protein) |  |
| Structure (InChI/SMILES or Protein Sequence) | CC(C)OC(=O)[C@H](C)N[P@](=O)(CO[C@H](C)Cn1cnc2c(N)ncnc21)Oc1ccccc1 |
Identifiers
| PDB | — |
| CAS-ID | 379270-37-8 |
| RxCUI | — |
| ChEMBL ID | CHEMBL2107825 |
| ChEBI ID | — |
| PubChem CID | 9574768 |
| DrugBank | DB09299 |
| UNII ID | EL9943AG5J (ChemIDplus, GSRS) |
Target
No data
Variants
No data
Financial
Revenue by drug
$
€
£
₣
Genvoya – Gilead Sciences
Mock data
Subscribe for the real data
Subscribe for the real data
Mock data
Subscribe for the real data
Subscribe for the real data
Biktarvy – Gilead Sciences
Mock data
Subscribe for the real data
Subscribe for the real data
Mock data
Subscribe for the real data
Subscribe for the real data
Odefsey – Gilead Sciences
Mock data
Subscribe for the real data
Subscribe for the real data
Mock data
Subscribe for the real data
Subscribe for the real data
Descovy – Gilead Sciences
Mock data
Subscribe for the real data
Subscribe for the real data
Mock data
Subscribe for the real data
Subscribe for the real data
Vemlidy – Gilead Sciences
Mock data
Subscribe for the real data
Subscribe for the real data
Mock data
Subscribe for the real data
Subscribe for the real data
Tabular view
Estimated US medical usage
No data
Trends
PubMed Central
Top Terms for Disease or Syndrome:
Mock data
Subscribe for the real data
Subscribe for the real data
Additional graphs summarizing 4,347 documents
View more details
Safety
Black-box Warning
Black-box warning for: Biktarvy, Descovy, Genvoya, Odefsey, Symtuza
Adverse Events
Top Adverse Reactions
Mock data
Subscribe for the real data
Subscribe for the real data
11,241 adverse events reported
View more details
© 2020-2023 Collaborative Drug Discovery Inc. (CDD) | Terms of Use